1. Early and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes.
- Author
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Mendes FS, Luizon MR, Lopes ACDS, Pereira DA, Evangelista FCG, Godoi LC, Dusse LM, and Alpoim PN
- Subjects
- Humans, Female, Pregnancy, Adult, Young Adult, Amidohydrolases genetics, Pre-Eclampsia genetics, Pre-Eclampsia blood, Haplotypes, Arginine analogs & derivatives, Arginine blood, Arginine genetics, Polymorphism, Genetic
- Abstract
Objective: To examine whether the DDAH2 promoter polymorphisms -1415G/A (rs2272592), -1151A/C (rs805304) and -449G/C (rs805305), and their haplotypes, are associated with PE compared with normotensive pregnant women, and whether they affect ADMA levels in these groups., Methods: A total of 208 pregnant women were included in the study and classified as early-onset (N=57) or late-onset PE (N =49), and as normotensive pregnant women (N = 102)., Results: Pregnant with early-onset PE carrying the GC and GG genotypes for the DDAH2 -449G/C polymorphism had increased ADMA levels (P=0.01). No association of DDAH2 polymorphisms with PE in single-locus analysis was found. However, the G-C-G haplotype was associated with the risk for late-onset PE., Conclusion: It is suggested that DDAH2 polymorphisms could affect ADMA levels in PE, and that DDAH2 haplotypes may affect the risk for PE., Competing Interests: Conflicts to interest: none to declare., (© 2024. Federação Brasileira de Ginecologia e Obstetrícia. All rights reserved.)
- Published
- 2024
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