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The regularities of the reduction of unsaturated nitriles containing the 2-adamantyl fragment with lithium aluminum hydride and nickel—aluminum alloy were studied. In both cases, the double bond and nitrile group were simultaneously reduced. The presence of bulky substituents in the substrate in the α-position to the adamantyl fragment and hydroxy groups significantly retards the process, and the 80–90% yield of the corresponding products is achieved only when the temperature is raised to 65 °C. In the case of using a nickel—aluminum alloy, its 4—6-fold excess is required. The calculation of the potential pharmacological activity of the synthesized compounds shows that they can have antiviral, analgesic, and antidiabetic activity. [ABSTRACT FROM AUTHOR]

Non-seeded ultrafast microwave synthesis of all-silica DDR zeolite was realized using 1-adamantane amine and tetraethylammonium hydroxide. XRD, SEM, NMR, FT-IR, TGA and nitrogen adsorption were used to characterize the obtained samples. The presence of TEAOH suppressed the formation of other phases which allowed the synthesis to be carried out at high temperature. High quality DDR crystals were obtained in only 30 min without seeding, which is the fastest synthesis up to now. 1-Adam serves as template for zeolite DDR and TEAOH is not occluded in zeolite channels. The ultra fast synthesis is the synergy of fast heating from microwave energy, fast kinetics (nucleation and crystallization) at high temperature and phase selectivity from the TEAOH. The obtained DDR crystals have similar properties as those prepared with traditional method. [ABSTRACT FROM AUTHOR]

A simple and efficient catalytic system including 3-methyl-4-oxa-5-azahomoadamantane and FeCl for aerobic oxidative synthesis of benzimidazoles from primary amines and o-phenylenediamine is presented. This process uses O as economic and green oxidant and water as green solvent, tolerates a wide range of substrates, and can afford the target products in moderate to excellent yields. [ABSTRACT FROM AUTHOR]

Addition of polyfunctionalized aryl, heteroaryl, and tertiary alkylmagnesium reagents to tertiary nitroalkanes at 25 °C in tetrahydrofuran produces, after reductive workup with FeCl2 and NaBH4 in ethanol, the corresponding polyfunctional secondary amines in high yields. [ABSTRACT FROM AUTHOR]

Novel building blocks for the synthesis of supramolecular components based on adamantane-bearing benzylamines were prepared. The binding properties of these amines and the corresponding acetamides towards β-cyclodextrin (β-CD) were studied using mass spectrometry, NMR spectrometry, isothermal titration calorimetry and semi-empirical calculations. It was found that all of the examined guests predominantly formed 1:1 inclusion complexes in an enthalpy-driven manner with association constants of the order of 102–103 M− 1. Stronger binding to the β-CD cavity was observed for guests with a longer spacer between the adamantane and benzene moieties and/or a 1,4-disubstituted benzene ring. [ABSTRACT FROM AUTHOR]