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Your search keyword '"Garcia, Yudith"' showing total 2 results
Start Over Author "Garcia, Yudith" Topic amines
2 results on '"Garcia, Yudith"'

1. The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders.

Author

Bi Y, Dzierba CD, Fink C, Garcia Y, Green M, Han J, Kwon S, Kumi G, Liang Z, Liu Y, Qiao Y, Zhang Y, Zipp G, Burford N, Ferrante M, Bertekap R, Lewis M, Cacace A, Westphal RS, Kimball D, Bronson JJ, and Macor JE

Subjects
Amides chemical synthesis, Amides chemistry, Amines chemical synthesis, Amines chemistry, Dose-Response Relationship, Drug, Humans, Molecular Structure, Structure-Activity Relationship, Amides pharmacology, Amines pharmacology, Central Nervous System Diseases drug therapy, Drug Discovery, Receptors, G-Protein-Coupled agonists
Abstract

Modulating GPR88 activity is suggested to have therapeutic utility in the treatment of CNS disorders, such as schizophrenia. This Letter will describe the discovery and SAR development of a class of potent GPR88 agonists., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Published
2015
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2. Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.

Author

Dzierba CD, Bi Y, Dasgupta B, Hartz RA, Ahuja V, Cianchetta G, Kumi G, Dong L, Aleem S, Fink C, Garcia Y, Green M, Han J, Kwon S, Qiao Y, Wang J, Zhang Y, Liu Y, Zipp G, Liang Z, Burford N, Ferrante M, Bertekap R, Lewis M, Cacace A, Grace J, Wilson A, Nouraldeen A, Westphal R, Kimball D, Carson K, Bronson JJ, and Macor JE

Subjects
Amines chemical synthesis, Amines chemistry, Dose-Response Relationship, Drug, Ethanolamines chemical synthesis, Ethanolamines chemistry, HEK293 Cells, Humans, Molecular Structure, Structure-Activity Relationship, Amines pharmacology, Drug Design, Ethanolamines pharmacology, Receptors, G-Protein-Coupled agonists
Abstract

Small molecule modulators of GPR88 activity (agonists, antagonists, or modulators) are of interest as potential agents for the treatment of a variety of psychiatric disorders including schizophrenia. A series of phenylglycinol and phenylamine analogs have been prepared and evaluated for their GPR88 agonist activity and pharmacokinetic (PK) properties., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Published
2015
Full Text
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