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1. Capillary electrochromatography-laser-induced fluorescence method for separation and detection of dansylated dialkylamine tags in encoded combinatorial libraries.

Author

Liu X, Takahashi LH, Fitch WL, Rozing G, Bayle C, and Couderc F

Subjects
Amines chemistry, Lasers, Sensitivity and Specificity, Amines analysis, Chromatography, Micellar Electrokinetic Capillary methods, Combinatorial Chemistry Techniques, Dansyl Compounds chemistry, Spectrometry, Fluorescence methods
Abstract

LC-fluorescence and LC-MS methods have been previously reported for use in decoding bead-based combinatorial libraries. We present the use of capillary electrochromatography (CEC) for highly selective decoding in combination with laser-induced fluorescence (LIF) detection for high sensitivity. The results are compared to prior data obtained using HPLC with fluorescence detection. The use of CEC shows promise for miniaturization and multiplexing for future applications, and the use of LIF detection can allow for detection at sub-pmol amounts.

Published
2001
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