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Your search keyword '"Manasyan, Luiza L."' showing total 2 results
Start Over Author "Manasyan, Luiza L." Topic amino acids
2 results on '"Manasyan, Luiza L."'

1. Asymmetric synthesis of new β-heterocyclic (S)-α-aminopropionic acids

Author

Saghyan, Ashot S., Simonyan, Hayarpi M., Stepanyan, Lala A., Ghazaryan, Samvel G., Geolchanyan, Arpine V., Manasyan, Luiza L., Ghochikyan, Vahe T., Ghochikyan, Tariel V., Hovhannisyan, Nelli A., Gevorgyan, Ashot, Iaroshenko, Viktor O., and Langer, Peter

Subjects
*ASYMMETRIC synthesis, *HETEROCYCLIC compounds, *PROPIONIC acid, *AMINO acids, *CHIRALITY, *CHEMICAL decomposition, *METAL complexes, *SCHIFF bases, *STEREOSELECTIVE reactions
Abstract

Abstract: The asymmetric synthesis of novel non-proteinogenic β-heterocyclic α-amino acids via the diastereoselective conjugate addition of heterocyclic nucleophiles to the dehydroalanine moiety of chiral Ni(II) complexes has been studied. The complexes were formed from the Schiff base of dehydroalanine using (S)-2-N-(N-benzylprolyl)aminobenzophenone as a chiral auxiliary. After decomposition of the complexes, the α-amino acids were isolated with 30–99% ee. [Copyright &y& Elsevier]

Published
2012
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2. Rapid asymmetric synthesis of amino acids via NiII complexes based on new fluorine containing chiral auxiliaries

Author

Saghyan, Ashot S., Dadayan, Ani S., Dadayan, Slavik A., Mkrtchyan, Anna F., Geolchanyan, Arpine V., Manasyan, Luiza L., Ajvazyan, Hrant R., Khrustalev, Victor N., Hambardzumyan, Hasmik H., and Maleev, Victor I.

Subjects
*ASYMMETRIC synthesis, *AMINO acids, *CHIRALITY, *FLUORINE, *NICKEL compounds, *METAL complexes, *AMIDES, *CHEMICAL reactions
Abstract

Abstract: New fluorine-containing chiral auxiliaries (S)-N-(2-benzoylphenyl)-1-(2-fluorobenzyl)-, (S)-N-(2-benzoylphenyl)-1-(3-fluorobenzyl)-, and (S)-N-(2-benzoylphenyl)-1-(4-fluorobenzyl)-pyrrolidine-2-carboxamide and their NiII complexes of Schiff bases with glycine and alanine have been synthesized. The greater efficiency of the complexes in terms of faster reaction rates and stereoselectivities in the asymmetric synthesis of (S)-α-amino acids has also been demonstrated. [ABSTRACT FROM AUTHOR]

Published
2010
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