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Start Over Author "Hutchings, Kim M." Topic aminoacyl-trna synthetases
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1. Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase

Author

Montgomery, Justin I., Toogood, Peter L., Hutchings, Kim M., Liu, Jia, Narasimhan, Lakshmi, Braden, Timothy, Dermyer, Michael R., Kulynych, Angela D., Smith, Yvonne D., Warmus, Joseph S., and Taylor, Clarke

Subjects
*AMINOACYL-tRNA synthetases, *STRUCTURE-activity relationships, *ETHERS, *ANTIBACTERIAL agents, *TRANSFER RNA, *LIGASES
Abstract

Abstract: A series of benzyl phenyl ethers (BPEs) is described that displays potent inhibition of bacterial phenylalanyl-tRNA synthetase. The synthesis, SAR, and select ADMET data are provided. [Copyright &y& Elsevier]

Published
2009
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