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A copper-catalyzed method for the synthesis of imidazo[1,2-a]pyridines with aminopyridines and nitroolefins using air as oxidation agent in a one-pot procedure has been developed. In this process, the reaction appears to be very general and suitable for construction of a variety of imidazo[1,2-a]pyridines.

Pyrido[1,2- a ]benzimidazoles, which show interesting and potentially useful biological activities, have drawn extensive attention from chemists. A straightforward copper acetate-oxidative one-pot synthesis of these compounds from 2-aminopyridines and phenylboronic acids through C–N bond formation and C–H bond activation was developed as a simple and convenient method. [ABSTRACT FROM AUTHOR]

An iron(III)-catalyzed one-pot three-component cross-coupling nitration reaction of 2-aminopyridines, aldehydes and nitroalkanes, straightforwardly forms imidazo[1,2- a]pyridine derivatives and is described in this report. The system shows good functional-group tolerance and proceeds smoothly in moderate to good yields. [ABSTRACT FROM AUTHOR]

Abstract: We have developed a highly efficient method in the presence of copper catalyst to form amides from aminopyridines and aldehydes. This method is simple, environmental benign and has practical advantages in the amide synthesis. [Copyright &y& Elsevier]

A simple protocol using air as the oxidant is developed for the synthesis of benzamides via oxidative amidation of benzaldehydes with aminopyridine derivatives. [ABSTRACT FROM AUTHOR]