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1. Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B.

Author

Gottfredsson M, Jessup CJ, Cox GM, Perfect JR, and Ghannoum MA

Subjects
Amphotericin B administration & dosage, Antifungal Agents administration & dosage, Drug Carriers, Liposomes, Microbial Sensitivity Tests, Amphotericin B pharmacology, Antifungal Agents pharmacology, Fungi drug effects, Fungi enzymology, Lysophospholipase metabolism
Abstract

It has been postulated that phospholipases of fungal origin can affect in vitro susceptibility testing of amphotericin B lipid complex (ABLC). We used specific phospholipase-deficient mutants of Candida albicans and Cryptococcus neoformans in susceptibility testing and demonstrated that extracellular fungal phospholipase activity does not influence the in vitro susceptibilities of these two fungi to ABLC.

Published
2001
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