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Your search keyword '"Sviridov, A. F."' showing total 6 results
Start Over Author "Sviridov, A. F." Topic amphotericin b
6 results on '"Sviridov, A. F."'

1. [Synthetic studies in the series of polyene macrolide antibiotics. 4. Synthesis of methyl-2,4,6-trideoxy-3-0-benzoyl-2,4-di-C-methyl- alpha-L-talo-hexopyranoside and 2,4,6-trideoxy-2,4-di-C-methyl-L- galactitol, the stereoisomers of the fragment C33-C38 of amphotericin B].

Author

Romanovich AIu, Chizhov OS, and Sviridov AF

Subjects
Amphotericin B chemical synthesis, Chemical Phenomena, Chemistry, Amphotericin B analogs & derivatives, Methylglycosides chemical synthesis
Abstract

Synthesis of methyl 2,4,6-trideoxy-3-O-benzoyl-2,4-di-C-methyl-alpha-L-talohexopyranoside and 2,4,6-trideoxy-2,4-di-C-methyl-L-galactitol, stereoisomers of the C33-C38 fragment of amphothericin B, is described.

Published
1988

2. [Synthetic studies in the series of polyene macrolide antibiotics. 5. Synthesis of methyl-2,4,6-trideoxy-2,4-di-C-methyl-alpha-L- gluco-hexopyranoside and methyl-2,4,6-trideoxy-2,4-di-C-methyl- alpha-L-manno-hexopyranoside, the stereoisomers of the C33-C38 fragment of amphotericin B].

Author

Romanovich AIu, Chizhov OS, and Sviridov AF

Subjects
Amphotericin B chemical synthesis, Chemical Phenomena, Chemistry, Stereoisomerism, Amphotericin B analogs & derivatives, Methylgalactosides chemical synthesis, Methylglycosides chemical synthesis
Abstract

The synthesis of the gluco- and manno-stereoisomers of amphotericin B is described.

Published
1988

3. [Synthetic studies of polyene macrolide antibiotics. 2. Synthesis of methyl-4,6-dideoxy-2,3-isopropylidene-4-C-methyl-alpha-L- mannopyranoside].

Author

Romanovich AIu, Chizhov OS, and Sviridov AF

Subjects
Chemical Phenomena, Chemistry, Methylmannosides chemical synthesis, Molecular Conformation, Polyenes chemical synthesis, Stereoisomerism, Amphotericin B chemical synthesis
Abstract

The synthesis of methyl 4,6-dideoxy-2,3-O-isopropylidene-4-C-methyl-alpha-L-mannopyranoside, a key intermediate on the preparation of C33-C38 fragment of amphotericin B, from L-rhamnose is described.

Published
1987

4. [Synthetic studies of polyene macrolide antibiotics. 3. Hydrogenation of methyl-6-deoxy-2,3-O-isopropylidene-4-methylene- alpha-L-lyxo-hexopyranoside].

Author

Romanovich AIu, Chizhov OS, and Sviridov AF

Subjects
Chemical Phenomena, Chemistry, Hydrogenation, Polyenes chemical synthesis, Stereoisomerism, Amphotericin B chemical synthesis, Methylglycosides chemical synthesis
Abstract

Experimental conditions of hydrogenation of the title compound are found (excess of Raney catalyst in benzene solution, 5 degrees C, 2h) to afford methyl 4,6-dideoxy-2,3-O-isopropylidene-4-C-methyl-alpha-L-mannopyranoside, the key intermediate in the synthesis of C33-C38 fragment of amphotericin B, with the yield as high as 57%.

Published
1987

5. [Synthetic studies of polyene macrolide antibiotics. 1. Synthesis of C1-C6- and C7-C12 fragments of amphotericin B from carbohydrate precursors].

Author

Sviridov AF, Romanovich AIu, and Chizhov OS

Subjects
Chemical Phenomena, Chemistry, Molecular Conformation, Polyenes chemical synthesis, Amphotericin B chemical synthesis, Carbohydrates
Abstract

Strategy of synthesis of polyene macrolide antibiotic amphotericin B using carbohydrates as starting material is discussed. The C1-C6 and C7-C12 fragments of amphotericin B are synthesized.

Published
1987

6. [Synthetic studies in the series of polyene macrolide antibiotics. 6. Synthesis of methyl-2,4,6-trideoxy-2,4-dimethyl-alpha-altro- hexopyranoside, the C33-C38 fragment of amphotericin B].

Author

Romanovich AIu, Chizhov OS, and Sviridov AF

Subjects
Amphotericin B chemical synthesis, Chemical Phenomena, Chemistry, Molecular Conformation, Amphotericin B analogs & derivatives, Methylglycosides chemical synthesis
Abstract

The synthesis of methyl 2,4,6-trideoxy-2,4-dimethyl-alpha-L-altro-hexopyranoside, having the configuration of the C33-C38 fragment of amphotericin B, is described.

Published
1988

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