1. In situ mixed donor synthesis of ampicillin with ethylene glycol co-solvent.
- Author
-
Deaguero AL and Bommarius AS
- Subjects
- Ampicillin analysis, Ampicillin chemistry, Biotechnology, Escherichia coli genetics, Escherichia coli metabolism, Escherichia coli Proteins genetics, Escherichia coli Proteins metabolism, Esterification, Ethylene Glycol metabolism, Penicillin Amidase genetics, Penicillin Amidase metabolism, Ampicillin metabolism, Ethylene Glycol chemistry
- Abstract
Ethylene glycol has the ability to act as a reactant when employed as a co-solvent for the enzymatic synthesis of ampicillin from (R)-phenylglycine methyl ester and 6-aminopenicillanic acid. The side reaction positively affects yield because its product, (R)-phenylglycine hydroxyethyl ester, is an intermediate for ampicillin synthesis., (© 2013 Wiley Periodicals, Inc.)
- Published
- 2014
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