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Your search keyword '"Kaulfers, PM"' showing total 3 results
Start Over Author "Kaulfers, PM" Topic ampicillin
3 results on '"Kaulfers, PM"'

1. [Infectious resistance to antibiotics in Haemophilus influenzae (author's transl)].

Author

Laufs R, Kaulfers PM, and Jahn G

Subjects
Chloramphenicol, Haemophilus Infections drug therapy, Humans, Meningitis drug therapy, Penicillin Resistance, Plasmids, R Factors, Tetracycline, Ampicillin pharmacology, Haemophilus influenzae drug effects
Abstract

Ampicillin-resistant Haemophilus influenzae does occur now in the FRG. In one isolate a plasmid with resistance genes (R-factor) could be demonstrated as cause of the ampicillin resistance. This R-factor influences production of a beta-lactamase of the TEM type which destroys ampicillin. The infectious nature of the ampicillin resistance was proven by the fact that it was transferable to other bacterial species through cocultivation. Parallel to ampicillin resistance tetracycline resistant Haemophilus influenzae has occurred in the FRG. Here the resistance was equally bound to plasmids. These R-factors are infectious as well. Molecular analysis of the 3 isolated resistance factors in Haemophilus influenzae showed that they carry the same resistance genes which are known from R-factors of Enterobacteriaceae. In the therapy of purulent infections due to Haemophilus influenzae such as childhood meningitis one can no longer rely on general ampicillin sensitivity of the offender. Apart from ampicillin and tetracycline resistant Haemophilus influenzae chloramphenicol resistance has been observed in a few cases.

Published
1978
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2. Molecular characterization of a plasmid specifying ampicillin resistance and its relationship to other R factors from Haemophilus influenzae.

Author

Laufs R and Kaulfers PM

Subjects
Cytosine analysis, DNA, Bacterial, Guanine analysis, Haemophilus influenzae drug effects, Haemophilus influenzae enzymology, Nucleic Acid Hybridization, Penicillinase biosynthesis, Transformation, Bacterial, Ampicillin pharmacology, Haemophilus influenzae genetics, Penicillin Resistance, Plasmids, R Factors
Published
1977
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3. Recurrent septicemias with Enterococcus faecium

Author

Drews D, Kaulfers Pm, Burdelski M, and H A Elsner

Subjects
Microbiology (medical), Male, medicine.medical_specialty, Extrahepatic Biliary Atresia, Adolescent, Enterococcus faecium, Penicillins, Gastroenterology, Recurrence, Internal medicine, Medicine, Humans, Blood culture, Abscess, Gram-Positive Bacterial Infections, medicine.diagnostic_test, biology, business.industry, Drug Resistance, Microbial, General Medicine, medicine.disease, Streptococcaceae, biology.organism_classification, Drug Resistance, Multiple, Surgery, Electrophoresis, Gel, Pulsed-Field, Liver Transplantation, Transplantation, Infectious Diseases, Male patient, Ampicillin, business, Complication, Ampicillin Resistance
Abstract

A 17-year-old male patient with extrahepatic biliary atresia underwent an orthotopic liver transplantation in September 1994. In blood cultures drawn in November and (6 weeks later) December 1994, from bile secretions in May 1995, stool in June 1995 an wound abscess in August 1995, ampicillin-resistant Enterococcus faecium was isolated. Pulsed-field gel electrophoresis demonstrated the clonal identity of the isolates. To our knowledge, repeated infections with the same E. faecium strain over a period of 9 months have not been described before. As multiple-resistant enterococci may colonize and reinfect liver transplant recipients for such a long time, preoperative antibiotic therapy should be administered cautiously in order not to select these organisms.

Published
1997

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