1. Taste memory trace disruption by AP5 administration in basolateral amygdala.
- Author
-
Traverso LM, Quintero E, Vargas JP, De la Casa LG, and Lopez JC
- Subjects
- Amygdala metabolism, Amygdala physiopathology, Animals, Association Learning drug effects, Association Learning physiology, Avoidance Learning drug effects, Avoidance Learning physiology, Excitatory Amino Acid Antagonists pharmacology, Extinction, Psychological drug effects, Extinction, Psychological physiology, Glutamic Acid metabolism, Inhibition, Psychological, Male, Memory physiology, Memory Disorders metabolism, Memory Disorders physiopathology, Neuropsychological Tests, Rats, Rats, Wistar, Synaptic Transmission drug effects, Synaptic Transmission physiology, Taste Perception physiology, 2-Amino-5-phosphonovalerate pharmacology, Amygdala drug effects, Conditioning, Classical drug effects, Memory drug effects, Memory Disorders chemically induced, Taste Perception drug effects
- Abstract
N-methyl-D-aspartate receptor has been related to learning and memory processes. Its characteristics make it a key candidate in the modulation of associative processes at physiological level. Traditionally, the main efforts have been directed to show its role in excitatory conditioning. Nevertheless, the studies that have analyzed its implication in inhibitory learning are scarce. We present an experiment where a preexposure effect on the conditioning (latent inhibition) is disrupted by 2-amino-5-phosphonopentanoic acid administered in basolateral amygdala. This data shows interference on taste memory trace, and attenuation of the inhibition effect.
- Published
- 2010
- Full Text
- View/download PDF