1. Platelet Count and Preoperative Haemoglobin Do Not Significantly Increase the Performance of Established Predictors of Renal Cell Carcinoma-Specific Mortality
- Author
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Karakiewicz, Pierre I., Trinh, Quoc-Dien, Lam, John S., Tostain, Jacques, Pantuck, Allan J., Belldegrun, Arie S., and Patard, Jean-Jacques
- Subjects
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RENAL cell carcinoma , *RENAL cancer , *CANCER diagnosis , *HEMOGLOBINS , *DIAGNOSIS ,BLOOD platelet examination - Abstract
Abstract: Objective: Anaemia and/or thrombocytosis were identified as independent predictors of poor survival in renal cell carcinoma (RCC). We tested the extent to which these markers worsen the prognosis in these patients. Methods: Analyses targeted 1828 patients with renal cell carcinoma. Univariable, multivariable, and predictive accuracy analyses addressed RCC-specific mortality (RCC-SM). Results: In univariable and multivariable analyses, both platelet count and preoperative haemoglobin level were statistically significant predictors of RCC-SM. However, neither platelet count nor preoperative haemoglobin level increased the combined multivariable accuracy of established RCC-SM (predictive accuracy gain=0.3%) predictors. Conclusions: Patients who present with severe anaemia or elevated platelets are at no higher risk of RCC-SM than that related to their stage, grade, histologic subtype, and Eastern Cooperative Oncology Group-Performance Status. [Copyright &y& Elsevier]
- Published
- 2007
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