Background and Objectives: A 58-year-old man developed progressive neurologic symptoms following a surgical procedure and postoperative epidural analgesia., Methods: Neurologic evaluation, magnetic resonance imaging, computed tomography, and electromyography indicated the presence of both arachnoiditis and Guillain-Barré syndrome. The patient was treated with plasmapheresis and methylprednisone., Results: The patient began to show clinical and electromyographic recovery but was lost to follow-up after his transfer to a rehabilitation facility., Conclusions: Anesthesiologists should be aware of the possible postoperative occurrence of rare neurologic disorders, both in patients who have received epidural analgesia and in those who have not, but they should not be deterred from using epidural analgesia by this isolated case.