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Objective: To investigate the influence of analgesic effect and hemodynamics of different doses of oxycodone hydrochloride combine dexmedetomidine in patients with abdominal surgery. Methods: 100 patients who underwent abdominal surgery in our hospital from March 2015 to March 2017 were selected in the study. According to the random number table method, the patients were divided into group A(application of 1.0 mg/kg oxycodone and 2.5 μg/kg dexmedetomidine), group B(application of 0.75 mg/kg oxycodone and 2.5 μg/kg dexmedetomidine), group C(application of 0.5 mg/kg oxycodone and 2.5 μg/kg dexmedetomidine), and group D(application of 1.0 mg/kg oxycodone), each group contained 25 cases. The satisfaction degree of analgesia effect in each group and hemodynamics indexes before anesthesia induction(T0), immediate intubation(T1), and 5 min after intubation(T2) were compared, and the adverse reactions of each group were statistically analyzed. Results: The satisfaction degree of analgesia effect in group A, B and C were significantly higher than those in group D, and the differences were statistically significant(all P<0.05), there was no significant difference in the satisfaction degree of analgesia effect between the three groups of A, B and C(P>0.05). The systolic blood pressure(SBP),diastolic blood pressure(DBP), mean arterial pressure(MAP) and heart rate(HR) levels in group A and B at T1 were higher than those in group C and D respectively, the differences were statistically significant(P<0.05). There was no statistically significant difference between SBP, DBP, MAP and HR at T0 and T2 in each groups(P>0.05). The levels of SBP, DBP, MAP and HR at T1 increased significantly compared with those at T0, but decreased significantly at T2, the differences were statistically significant(P<0.05). The total incidence of adverse reactions in group B was 12.00%, which was significantly lower than 36.00% in group A, 44.00% in group C and40.00% in group D, and the differences were statistically significant(all P<0.05). Conclusion: Different doses of oxycodone hydrochloride combine dexmedetomidine have better anesthesia on the analgesic effect of abdominal surgery patients, it has some influence on the hemodynamic level of the patients, but as time goes on, it gradually decreases. The treatment with 2.5 μg/kg dexmedetomidine and 0.75mg/kg oxycodone hydrochloride compound anesthesia of the higher safety, which is worthy of clinical application. [ABSTRACT FROM AUTHOR]