1. [High anion gap metabolic acidosis (pyroglutamic acidosis) induced by chronic acetaminophen use].
- Author
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Tchougang Nono J, Mistretta V, Noirot I, Canivet JL, and Damas P
- Subjects
- Acetaminophen administration & dosage, Analgesics, Non-Narcotic administration & dosage, Female, Humans, Middle Aged, Acetaminophen adverse effects, Acidosis chemically induced, Analgesics, Non-Narcotic adverse effects, Prescription Drug Overuse adverse effects
- Abstract
Acetaminophen is the most consumable analgesic in the world in the form of medical prescription or self-medication. It is one of the active ingredients most often involved in voluntary poisoning. Lethal dose of acetaminophen classically induces acute hepatic failure on hepatic necrosis. Chronic intake of sub-lethal doses (i.e. near recommended therapeutic doses) of acetaminophen in the presence of certain risk factors may be responsible for another much less recognized pathological manifestation: severe metabolic acidosis with an increased anion gap due to the accumulation of 5-oxoproline or pyroglutamic acid.
- Published
- 2018