1. Pain management in hematological patients with major organ dysfunctions and comorbid illnesses.
- Author
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Niscola P, Tendas A, Giovannini M, Scaramucci L, Cupelli L, Ferrannini M, Brunetti GA, Bondanini F, Palumbo R, Perrotti A, Romani C, Cartoni C, Efficace F, and de Fabritiis P
- Subjects
- Adjuvants, Pharmaceutic administration & dosage, Adjuvants, Pharmaceutic therapeutic use, Analgesics administration & dosage, Analgesics pharmacokinetics, Analgesics pharmacology, Analgesics, Opioid administration & dosage, Analgesics, Opioid pharmacokinetics, Analgesics, Opioid pharmacology, Analgesics, Opioid therapeutic use, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Anti-Inflammatory Agents, Non-Steroidal pharmacokinetics, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Comorbidity, Hematologic Diseases epidemiology, Humans, Kidney Diseases drug therapy, Kidney Diseases etiology, Liver Diseases drug therapy, Liver Diseases etiology, Pain etiology, Analgesics therapeutic use, Hematologic Diseases complications, Hematologic Diseases drug therapy, Pain drug therapy, Pain Management methods
- Abstract
Background: Organ dysfunctions and medical complications, such as renal failure, liver impairment, coagulation disorders, cardiovascular and respiratory illnesses, may hamper an adequate pain management in haematological patients., Aim: To summarize current knowledge on pain management in hematological patients presenting major organ dysfunctions and comorbidity. We also attempted to provide recommendations to optimize analgesia and to minimize side effects in the setting of medically compromised and frail haematological patients., Methods: A systematic search of the literature, using relevant key words, was conducted in PubMed., Results and Conclusions: Pain in hematological patients is a common symptom and is often multi-factorial. Most pharmacotherapeutic measures, including causal therapies, analgesics and adjuvant agents routinely applied in pain management, may also be used in the setting of clinical frailty and medical comorbidities; however, comprehensive clinical and functional patient's evaluations and a careful consideration of expected benefits and potential adverse events are required. more...
- Published
- 2012
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