1. Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controlled trial of selenium supplementation.
- Author
-
Tara, Fatemeh, Rayman, Margaret P., Boskabadi, Hassan, Ghayour-Mobarhan, Majid, Sahebkar, Amirhossein, Alamdari, Daryoush H., Razavi, Behjat S., Tavallaie, Shima, Azimi-Nezhad, Mohsen, Shakeri, Mohammad T., Oladi, Mohammadreza, Yazarlu, Omid, Ouladan, Shaida, Teimoori Sangani, Maryam, Rezagholizadeh Omran, Fatemeh, and Ferns, Gordon
- Subjects
- *
SELENIUM , *ANALYSIS of variance , *ANTIOXIDANTS , *COMPUTER software , *DIETARY supplements , *ENZYME-linked immunosorbent assay , *OXIDIZING agents , *PREGNANCY , *RESEARCH funding , *STATISTICAL sampling , *STATISTICS , *T-test (Statistics) , *U-statistics , *DATA analysis , *OXIDATIVE stress , *BODY mass index , *BLIND experiment , *WAIST-hip ratio , *METABOLISM , *PHYSIOLOGY , *THERAPEUTICS - Abstract
Objective: We assessed the impact of selenium, a trace element with antioxidant properties on a simple measure of oxidative stress in pregnant women. Study design: A novel assay of prooxidant-antioxidant balance (PAB) was applied in a double-blind, placebo-controlled study of selenium supplementation in pregnancy. We measured the prooxidant burden and the antioxidant capacity simultaneously in one assay, thereby calculating a redox index. A total of 166 primigravid pregnant women in the first trimester of pregnancy, were randomized to receive 100 μg of selenium (n=83) or placebo (n=83) per day until delivery. PAB values and serum selenium concentrations were measured at baseline and at the end of study. Results: Pretreatment demographic data and biochemical indices including serum selenium concentrations did not differ significantly between the groups. The drop-out rates for the groups were 22/83 and 19/83 for the selenium and placebo groups, respectively. Supplementation with selenium was associated with a significant increase in mean serum selenium concentration (P<0.001) but without significant change in mean PAB value. In contrast, mean serum selenium concentration remained unchanged and mean PAB values increased significantly (P<0.05 in the control group). Conclusion: Our findings suggest that selenium supplementation may reduce oxidative stress associated with pregnancy. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF