1. Cytotoxic Compounds from the Stem Bark of Two subsp. of Bersama abyssinica
- Author
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Khadija Hassan, Lukas Brieger, Kibrom Gebreheiwot Bedane, Carsten Strohmann, Josphat C. Matasyoh, Divinah K Nyamboki, and Michael Spiteller
- Subjects
Pharmacology ,Stem bark ,biology ,Traditional medicine ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Pharmaceutical Science ,medicine.disease_cause ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,Cell culture ,Staphylococcus aureus ,Drug Discovery ,medicine ,Molecular Medicine ,Cytotoxic T cell ,MTT assay ,Cytotoxicity ,Two-dimensional nuclear magnetic resonance spectroscopy ,Bersama abyssinica - Abstract
Three new bufadienolides, namely, paulliniogenin A (1), paulliniogenin B (2), and 16β-formyloxybersamagenin 1,3,5-orthoacetate (3), together with two known bufadienolides and six known phenolic substances, were isolated from the stem bark of Bersama abyssinica subsp. abyssinica and B. abyssinica subsp. paullinioides. The structures of the compounds were elucidated based on their NMR and HRMS data analyses. The relative configurations were defined by single-crystal X-ray crystallography and NOESY correlations. Cytotoxicity against the L929 and KB3.1 cancer cell lines of the isolated compounds was investigated using an MTT assay. Paulliniogenin A (1) and 16β-hydroxybersamagenin-1,3,5-orthoacetate (4) showed cytotoxicity against the KB3.1 cell line with IC50 values of 1.4 ± 0.77 and 1.6 ± 0.81 μM, respectively. Moreover, paulliniogenin A (1) and paulliniogenin B (2) demonstrated weak activity against Staphylococcus aureus.
- Published
- 2021