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Start Over Author "M, Sundgren" Topic analytical chemistry
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3. Flow injection extraction applied to dissolution rate studies of felodipine tablets

Author

M. Sundgren, A. Torstensson, and L. Nord

Subjects
Clinical Biochemistry, Pharmaceutical Science, Derivative, Analytical Chemistry, Spectrophotometry, Drug Discovery, medicine, Dissolution testing, Solubility, Dissolution, Spectroscopy, Flow injection analysis, Chromatography, Felodipine, Molecular Structure, medicine.diagnostic_test, Chemistry, Extraction (chemistry), Reproducibility of Results, Kinetics, Spectrophotometry, Ultraviolet, Chloroform, Chromatography, Liquid, Tablets, medicine.drug
Abstract

A flow injection analysis (FIA) extraction method has been developed for the analysis of felodipine tablets in connection with dissolution rate testing. The water-soluble oxidation product of felodipine, a pyridine derivative, was extracted into chloroform and measured at 275 nm spectrophotometrically. The FIA-extraction method has been compared with the present liquid chromatographic (LC) method. The sampling rate for the FIA-extraction (60 samples h-1) is 5 times higher than for the LC method. The FIA-extraction method has a standard deviation of 1% for both standards and samples which is the same as for the LC method.

Published
1989
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