1. From estrogen to androgen receptor: a new pathway for sex hormones in prostate
- Author
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Yeh, Shuyuan, Miyamoto, Hiroshi, Shima, Hiroki, and Chang, Chawnshang
- Subjects
Hormones, Sex -- Receptors ,Prostate cancer -- Research ,Androgens -- Research ,Science and technology - Abstract
While all three coactivators [ARA.sub.70], steroid receptor coactivator 1, and RAC3/ACTR can enhance androgen receptor (AR) transcriptional activity at 1 nM dihydrotestosterone, we here demonstrate that only [ARA.sub.70] can induce AR transcriptional activity >30-fold in the presence of 10 nM 17[Beta]-estradiol (E2), but not diethylstilbestrol. The significance of this newly described E2-induced AR transcriptional activity in DU145 human prostate cancer cells was further strengthened by finding patients with Reifenstein partial-androgen-insensitive syndrome that fail in the E2-AR-[ARA.sub.70] pathway. Together, our data suggest, for the first time, testosterone/dihydrotestosterone may not be the only ligands for the AR. E2 represents another important natural ligand for AR that may play an essential role for the AR function and the development of the male reproductive system.
- Published
- 1998