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Your search keyword '"Lyttelton M"' showing total 2 results
Start Over Author "Lyttelton M" Topic anemia, aplastic
2 results on '"Lyttelton M"'

1. Sustained trilineage response in a patient with ALG-resistant severe aplastic anaemia after treatment with G-CSF, erythropoietin and cyclosporin A: association of recovery with marked elevation of serum alkaline phosphatase.

Author

Weide R, Lyttelton M, Samson D, Görg C, Köppler H, Pflüger KH, and Havemann K

Subjects
Adolescent, Anemia, Aplastic blood, Anemia, Aplastic enzymology, Antilymphocyte Serum therapeutic use, Drug Resistance, Drug Therapy, Combination, Female, Humans, Prednisolone therapeutic use, Alkaline Phosphatase blood, Anemia, Aplastic therapy, Cyclosporine therapeutic use, Erythropoietin therapeutic use, Granulocyte Colony-Stimulating Factor therapeutic use
Abstract

Aplastic anaemia is characterized by multilineage bone marrow failure resulting in pancytopenia. We have successfully treated a young woman with severe aplastic anaemia (SAA) who was resistant to antilymphocyte globulin (ALG) and corticosteroids, with a combination therapy consisting of erythropoietin, cyclosporin A and granulocyte-colony stimulating factor (G-CSF). The patient received erythropoietin and CSA for a period of 10 months without success before G-CSF treatment was started. After 6 weeks of G-CSF therapy she responded with a sustained trilineage recovery. This suggests that immunosuppression together with haemopoietic growth factors may be an effective treatment in patients with SAA who are ALG resistant and cannot be treated by BMT.

Published
1993
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2. Prolonged remission of Epstein-Barr virus associated lymphoma secondary to T cell-depleted bone marrow transplantation

Author

Lyttelton, M. P., Browett, P. J., Brenner, M. K., Norton, J. D., Kolman, J. L., Mcgee, J. O., Stephen Hamilton-Dutoit, Hoffbrand, A. V., and Prentice, H. G.

Subjects
Adult, Male, Herpesvirus 4, Human, Lymphoma, Non-Hodgkin, T-Lymphocytes, Remission Induction, Restriction Mapping, Anemia, Aplastic, Lymphocyte Depletion, Tumor Virus Infections, Humans, Transplantation, Homologous, DNA Probes, Bone Marrow Transplantation

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