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Your search keyword '"Alex W. Macharia"' showing total 2 results
Start Over Author "Alex W. Macharia" Topic anemia, sickle cell
2 results on '"Alex W. Macharia"'

1. The population dynamics of hemoglobins A, A

Author

Alex W, Macharia, Sophie, Uyoga, Carolyne, Ndila, Gideon, Nyutu, Johnstone, Makale, Metrine, Tendwa, Emily, Nyatichi, John, Ojal, Sarah, Atkinson, and Thomas N, Williams

Subjects
Male, Hemoglobin, Sickle, Genetic Variation, Infant, Hemoglobin A, Anemia, Sickle Cell, Prognosis, Kenya, Hemoglobinopathies, alpha-Thalassemia, Humans, Female, Hemoglobin A2, Online Only Articles, Biomarkers, Fetal Hemoglobin
Published
2018

2. The clinical epidemiology of sickle cell anemia In Africa

Author

Alex W, Macharia, George, Mochamah, Sophie, Uyoga, Carolyne M, Ndila, Gideon, Nyutu, Johnstone, Makale, Metrine, Tendwa, Emily, Nyatichi, John, Ojal, Mohammed, Shebe, Kennedy O, Awuondo, Neema, Mturi, Norbert, Peshu, Benjamin, Tsofa, J Anthony G, Scott, Kathryn, Maitland, and Thomas N, Williams

Subjects
Male, Delayed Diagnosis, Adolescent, Bacteremia, Anemia, Sickle Cell, Comorbidity, Patient Admission, parasitic diseases, Humans, Meningitis, Child, Developing Countries, Research Articles, Retrospective Studies, Diagnostic Tests, Routine, Malnutrition, Infant, Newborn, Infant, Kenya, Malaria, Stroke, Early Diagnosis, Child, Preschool, Population Surveillance, Female, Disease Susceptibility, Research Article
Abstract

Sickle cell anemia (SCA) is the commonest severe monogenic disorders of humans. The disease has been highly characterized in high‐income countries but not in sub‐Saharan Africa where SCA is most prevalent. We conducted a retrospective cohort study of all children 0–13 years admitted from within a defined study area to Kilifi County Hospital in Kenya over a five‐year period. Children were genotyped for SCA retrospectively and incidence rates calculated with reference to population data. Overall, 576 of 18,873 (3.1%) admissions had SCA of whom the majority (399; 69.3%) were previously undiagnosed. The incidence of all‐cause hospital admission was 57.2/100 person years of observation (PYO; 95%CI 52.6–62.1) in children with SCA and 3.7/100 PYO (95%CI 3.7–3.8) in those without SCA (IRR 15.3; 95%CI 14.1–16.6). Rates were higher for the majority of syndromic diagnoses at all ages beyond the neonatal period, being especially high for severe anemia (hemoglobin

Published
2017

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