4 results on '"Gorio, C"'
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2. HbS/β+ thalassemia: Really a mild disease? A National survey from the AIEOP Sickle Cell Disease Study Group with genotype-phenotype correlation.
- Author
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Notarangelo LD, Agostini A, Casale M, Samperi P, Arcioni F, Gorello P, Perrotta S, Masera N, Barone A, Bertoni E, Bonetti E, Burnelli R, Casini T, Del Vecchio GC, Filippini B, Giona F, Giordano P, Gorio C, Marchina E, Nardi M, Petrone A, Colombatti R, Sainati L, and Russo G
- Subjects
- Adolescent, Adult, Alleles, Anemia, Sickle Cell epidemiology, Child, Child, Preschool, Female, Genetic Association Studies, Humans, Infant, Italy epidemiology, Male, Middle Aged, Public Health Surveillance, Retrospective Studies, Young Adult, beta-Thalassemia epidemiology, Anemia, Sickle Cell diagnosis, Anemia, Sickle Cell genetics, Genotype, Hemoglobin, Sickle genetics, Phenotype, beta-Globins genetics, beta-Thalassemia diagnosis, beta-Thalassemia genetics
- Abstract
Objectives: HbS/β+ patients' presence in Italy increased due to immigration; these patients are clinically heterogeneous, and specific guidelines are lacking. Our aim is to describe a cohort of HbS/β+ patients, with genotype-phenotype correlation, in order to offer guidance for clinical management of such patients., Methods: Retrospective cohort study of HbS/β+ patients among 15 AIEOP Centres., Results: A total of 41 molecularly confirmed S/β+ patients were enrolled (1-55 years, median 10.9) and classified on β+ mutation: IVS-I-110, IVS-I-6, promoter, and "others." Prediagnostic events included VOC 16/41 (39%), ACS 6/41 (14.6%), sepsis 3/41 (3.7%), and avascular necrosis 3/41 (7,3%). Postdiagnostic events were VOC 22/41 (53.6% %), sepsis 4/41 (9.7%), ACS 4/41 (9.7%), avascular necrosis 3/41 (7.3%), aplastic crisis 2/41 (4.8%), stroke 1/41 (2.4%), ACS 1/41 (2.4%), and skin ulcerations 1/41 (2.4%). The IVS-I-110 group presented the lowest median age at first SCD-related event (P = .02 vs promoter group) and the higher median number of severe events/year (0.26 events/patient/year) (P = .01 vs IVS-I-6 and promoter groups). Promoter group presented a specific skeletal phenotype. Treatment regimen applied was variable among the centers., Conclusions: HbS/β+ is not always a mild disease. Patients with IVS-I-110 mutation could benefit from a standard of care like SS and S/β° patients. Standardization of treatment is needed., (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2020
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3. Acute events in children with sickle cell disease in Italy during the COVID-19 pandemic: useful lessons learned
- Author
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Agostino Nocerino, Laura Sainati, Serena Ilaria Tripodi, Chiara Gorio, Marco Zecca, Beatrice Filippini, Antonella Sau, Beatrice Coppadoro, Raffaella Colombatti, Maddalena Migliavacca, Paola Giordano, Maria Luisa Casciana, Silverio Perrotta, Valentina Baretta, Piera Samperi, Fiorina Giona, Francesco Arcioni, Chiara Piccolo, Paola Corti, Maddalena Casale, Lucia Dora Notarangelo, Giovanna Russo, Paola Saracco, Giovanni Palazzi, Daniela Cuzzubbo, Gian Carlo Del Vecchio, Simone Cesaro, Vania Munaretto, Maurizio Miano, Vincenzo Voi, Silvia Fasoli, Angelica Barone, Munaretto, V., Voi, V., Palazzi, G., Notarangelo, L. D., Corti, P., Baretta, V., Casale, M., Barone, A., Cuzzubbo, D., Samperi, P., Tripodi, S., Giona, F., Miano, M., Nocerino, A., Del Vecchio, G. C., Piccolo, C., Sau, A., Filippini, B., Casciana, M. L., Arcioni, F., Migliavacca, M., Saracco, P., Gorio, C., Cesaro, S., Perrotta, S., Zecca, M., Giordano, P., Fasoli, S., Coppadoro, B., Russo, G., Sainati, L., and Colombatti, R.
- Subjects
Male ,2019-20 coronavirus outbreak ,Vaso‐occlusive crisis ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Vaso-occlusive crisi ,Anemia, Sickle Cell ,Disease ,Hospital ,children ,COVID‐19 ,acute chest ,Correspondence ,Pandemic ,Acute Chest Syndrome ,Medicine ,Humans ,Child ,Vaso-occlusive crisis ,Emergency Service ,business.industry ,COVID-19 ,Anemia ,Hematology ,medicine.disease ,Virology ,Sickle Cell ,Italy ,sickle cell disease ,Female ,Emergency Service, Hospital ,business ,Human - Published
- 2021
4. HbS/β+ thalassemia: Really a mild disease? A National survey from the AIEOP Sickle Cell Disease Study Group with genotype-phenotype correlation
- Author
-
Notarangelo, L. D., Agostini, A., Casale, M., Samperi, P., Arcioni, F., Gorello, P., Perrotta, S., Masera, N., Barone, A., Bertoni, E., Bonetti, E., Burnelli, R., Casini, T., Del, Vecchio, Filippini, G. C., Giona, B., Giordano, F., Gorio, P., Marchina, C., Nardi, E., Petrone, M., Colombatti, A., Sainati, R., Russo, L. r., Email Author View Correspondence (jump link), G., Notarangelo, L. D., Agostini, A., Casale, M., Samperi, P., Arcioni, F., Gorello, P., Perrotta, S., Masera, N., Barone, A., Bertoni, E., Bonetti, E., Burnelli, R., Casini, T., Del Vecchio, G. C., Filippini, B., Giona, F., Giordano, P., Gorio, C., Marchina, E., Nardi, M., Petrone, Angelo, Colombatti, R., Sainati, L., and Russo, G.
- Subjects
Male ,Thalassemia ,Hemoglobin, Sickle ,HbS/β+ thalassemia ,Italy ,Sickle cell disease ,children ,genotype ,phenotype ,Avascular necrosis ,Disease ,beta-Globins ,Gastroenterology ,Sickle ,0302 clinical medicine ,Genotype ,Public Health Surveillance ,Child ,Stroke ,Anemia ,Hematology ,General Medicine ,Middle Aged ,Sickle Cell ,Phenotype ,030220 oncology & carcinogenesis ,Child, Preschool ,Cohort ,Female ,HbS ,beta plus thalassemia ,Adult ,medicine.medical_specialty ,Adolescent ,Anemia, Sickle Cell ,Sepsis ,03 medical and health sciences ,Young Adult ,Internal medicine ,medicine ,Humans ,Hemoglobin ,Preschool ,Alleles ,Genetic Association Studies ,Infant ,Retrospective Studies ,beta-Thalassemia ,business.industry ,Retrospective cohort study ,medicine.disease ,business ,030215 immunology - Abstract
Objectives: HbS/β+ patients’ presence in Italy increased due to immigration; these patients are clinically heterogeneous, and specific guidelines are lacking. Our aim is to describe a cohort of HbS/β+ patients, with genotype-phenotype correlation, in order to offer guidance for clinical management of such patients. Methods: Retrospective cohort study of HbS/β+ patients among 15 AIEOP Centres. Results: A total of 41 molecularly confirmed S/β+ patients were enrolled (1-55years, median 10.9) and classified on β+ mutation: IVS-I-110, IVS-I-6, promoter, and “others.” Prediagnostic events included VOC 16/41 (39%), ACS 6/41 (14.6%), sepsis 3/41 (3.7%), and avascular necrosis 3/41 (7,3%). Postdiagnostic events were VOC 22/41 (53.6% %), sepsis 4/41 (9.7%), ACS 4/41 (9.7%), avascular necrosis 3/41 (7.3%), aplastic crisis 2/41 (4.8%), stroke 1/41 (2.4%), ACS 1/41 (2.4%), and skin ulcerations 1/41 (2.4%). The IVS-I-110 group presented the lowest median age at first SCD-related event (P=.02 vs promoter group) and the higher median number of severe events/year (0.26 events/patient/year) (P=.01 vs IVS-I-6 and promoter groups). Promoter group presented a specific skeletal phenotype. Treatment regimen applied was variable among the centers. Conclusions: HbS/β+ is not always a mild disease. Patients with IVS-I-110 mutation could benefit from a standard of care like SS and S/β° patients. Standardization of treatment is needed.
- Published
- 2019
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