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Diagnosis and management of feto-maternal red blood cell incompatibilities are a regular concern for neonatologists on maternity wards. Despite of the tremendous development of antenatal and post-natal therapies and prevention, haemolytic disease of the newborn has not disappeared. ABO incompatibility is the most frequent cause of neonatal haemolytic disease (HDN), and RH4, RH3, and KEL1 are today increasing compared to RH1 disease. The management of HDN begins in the perinatal period and will end after 2-3 months post-natal age. Its success relies on anticipation and close interactions in between obstetricians, neonatologists, biologists, and transfusion team. [ABSTRACT FROM AUTHOR]

Hereditary spherocytosis (HS) is a familial hemolytic disorder with marked heterogeneity of clinical features, ranging from an asymptomatic condition to a fulminant hemolytic anemia. Although a positive family history of spherocytosis increases the risk for this disorder, it may be sporadic in some cases. In severe cases the disorder may be detected in early childhood, but in mild cases it may go unnoticed until later in adult life. A 27-year-old Nigerian woman presented with mild anemia, jaundice, splenomegaly and a history of multiple blood transfusion. Blood film showed about 70% spherocytes, reticulocytosis of 6.5%, increased osmotic fragility test and a negative direct antiglobulin test. She was managed conservatively on nutritional supplements and a significant regression of symptoms after 6 months was achieved. [ABSTRACT FROM AUTHOR]