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OBJECTIVE The aim: Evaluation of stress-protective effects of various anesthetic techniques on Cesarean section (CS). PATIENTS AND METHODS Materials and methods: 127 pregnant women who delivered by cesarean section, were divided into 4 subgroups: 1a (n = 31) - general anesthesia (GA) with ketamine, 1b (n = 31) - GA with sodium thiopental, 2a (n = 31) - spinal anesthesia (SA), 2b (n = 34) - SA with intravenous administration of ondansetron at a dose of 8 mg. The assessment was performed at 5 stages: 1 - initial; 2 - infant extraction; 3 - 6 hours after surgery; 4 - 12 hours after surgery. RESULTS Results: At stage 2, insulin levels in 1a and 1b subgroups decreased by 23.9% and 34.1%, while in 2a and 2b subgroups there were no significant changes. There was an increase in the levels of cortisol, prolactin and cortisol/insulin ratio at the 2 and 3 stages in the 1a and 1b subgroups. Pain intensity increased by the 3 stage in patients of all groups. It was the highest in the 1a and 1b subgroups. At the 4 stage, pain intensity was reduced in all groups, remaining significantly higher in patients of 1a and 1b subgroups. CONCLUSION Conclusions: The dynamics of the content of stress hormones, the pain intensity in patients undergoing CS under SA give reason to consider this method as an optimal and adequate one for protection from surgery stress.