1. Mesenchymal Stem Cell Homing: The Devil Is in the Details
- Author
-
Grace S.L. Teo and Jeffrey M. Karp
- Subjects
Integrins ,Angiogenesis ,Mesenchyme ,Chemotaxis ,Mesenchymal stem cell ,Cytological Techniques ,Mesenchymal Stem Cells ,Cell Biology ,Biology ,Mesenchymal Stem Cell Transplantation ,Cell therapy ,medicine.anatomical_structure ,Phenotype ,Cell Movement ,Immunology ,Genetics ,medicine ,Molecular Medicine ,Animals ,Humans ,Stem cell ,Neuroscience ,Homing (hematopoietic) - Abstract
The study of MSC trafficking is clinically relevant for minimally invasive cell therapy to promote regeneration of damaged tissue, to treat inflammation, and to promote angiogenesis. However, these studies are complicated by the diverse methods used to culture, characterize, and deliver MSCs and by the variety of methods used to assess homing events. This review provides a critical analysis of the methods used to track homing of exogenously infused MSCs and discusses strategies for enhancing their trafficking to particular tissues.
- Full Text
- View/download PDF