1. Cancer surgery induces inflammation, immunosuppression and neo-angiogenesis, but is it influenced by analgesics?
- Author
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Marc De Kock, Olivier Simonet, Patrice Forget, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'anesthésiologie, UCL - (SLuc) Service d'anesthésiologie, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, and UCL - SSS/IREC - Institut de recherche expérimentale et clinique
- Subjects
Oncology ,medicine.medical_specialty ,Neo angiogenesis ,Cancer in the Elderly ,Angiogenesis ,medicine.medical_treatment ,Analgesic ,Inflammation ,General Biochemistry, Genetics and Molecular Biology ,Cancer Therapeutics ,Immunomodulation ,Pain Management: Chronic Clinical ,Immune system ,Head & Neck Cancers ,Internal medicine ,Integrative Physiology ,medicine ,Genitourinary Cancers ,General Pharmacology, Toxicology and Pharmaceutics ,Immune Response ,Gynecological Cancers ,General Immunology and Microbiology ,business.industry ,Cancer ,Immunosuppression ,General Medicine ,Articles ,medicine.disease ,Cardiovascular Physiology/Circulation ,Immunology ,Commentary ,Oncology Agents ,Perioperative Critical Care ,medicine.symptom ,business ,Cancer surgery - Abstract
Surgery remains a main part of the treatment of most solid tumors. Paradoxically, rapid disease progression may be a consequence of surgery in patients presenting with a dysregulated inflammatory response, and increased angiogenesis consequent to a suppressed antitumoral immune response. Physicians taking care of cancer patients should be aware of the important findings that indicate that analgesic techniques could play a role in these phenomena.
- Published
- 2013