1. Cell therapy of burns
- Author
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Alexaline, M., Thepenier, C., Trouillas, M., Leclerc, T., Desmouliere, A., Benderriter, M., Centre de Transfusion Sanguine des Armées (CTSA), Service de Santé des Armées, Hôpital d'instruction des Armées Percy, Faculté de Pharmacie [Limoges], Université de Limoges (UNILIM), and Institut de Radioprotection et de Sûreté Nucléaire (IRSN)
- Subjects
skin transplantation ,[SDV]Life Sciences [q-bio] ,keratinocyte ,wound healing ,tissue regeneration ,adipocyte ,paracrine signaling ,angiopoietin 1 ,angiogenesis ,skin graft ,fibronectin ,collagen type 6 ,burn ,cartilage cell ,CD34 antigen ,human ,tissue repair ,cell lineage ,protein expression ,collagen type 1 ,endoglin ,cell culture ,C reactive protein ,vasculotropin ,article ,CD45 antigen ,Thy 1 antigen ,cell adhesion ,CD14 antigen ,cell differentiation ,osteoblast ,5' nucleotidase ,mesenchymal stem cell transplantation ,antigen expression ,disease severity ,cell therapy ,cell transdifferentiation ,radiation injury - Abstract
Severe burns remain a life threatening local and general inflammatory disease with often heavy sequelae, despite remarkable progress in their treatment in the last three decades. Cultured epidermal autografts, the first and still up-to-date cell therapy of burns, played a key role in that progress, and their drawbacks should be reduced with cultured dermal-epidermal substitutes. This review focuses on what could be the next major breakthrough in cell therapy of burns: mesenchymal stromal cells (MSCs). After summarizing current knowledge, including our own clinical experience, about MSCs in the pioneer field of cell therapy in radiation-induced burns, we discuss the strong rationale supporting the potential interest of MSCs in the treatment of thermal burns, including limited but promising pre-clinical and clinical data in wound healing and other acute inflammatory diseases. © 2012 The authors and IOS Press. All rights reserved.
- Published
- 2012
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