1. Nor-lupane triterpenoid and guaiane sesquiterpenoids from Schefflera venulosa.
- Author
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Peng, Li-Yan, Xu, Gang, He, Juan, Wu, Xing-De, Dong, Liao-Bin, Gao, Xiu, Cheng, Xiao, Su, Jia, Li, Yan, Dong, Wen-Ming, and Zhao, Qin-Shi
- Subjects
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ALTERNATIVE medicine , *ANIMAL experimentation , *ANTI-inflammatory agents , *BIOLOGICAL models , *PHYSICAL & theoretical chemistry , *LEAVES , *MACROPHAGES , *MEDICINAL plants , *MICE , *NITRIC oxide , *NUCLEAR magnetic resonance spectroscopy , *PLANT extracts , *DESCRIPTIVE statistics , *IN vitro studies , *PHARMACODYNAMICS - Abstract
A novel nor-lupane triterpenoid, 3-oxo-29 α -hydroxy-17 β ,20-epoxy-28-norlupane ( 1 ), and two new guaiane sesquiterpenoids, schvenols A–B ( 2 – 3 ), has been isolated from leaves of Schefflera venulosa . Structures of the new compounds were elucidated on the basis of their spectroscopic methods, including 1D and 2D NMR techniques. And the structure of 1 was further confirmed by the X-ray diffraction analysis. None of the compounds showed inhibitory effects on NO release in LPS-stimulated RAW 264.7 macrophage cell line. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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