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Your search keyword '"Williams, Nerissa T."' showing total 2 results
Start Over Author "Williams, Nerissa T." Topic animal experimentation
2 results on '"Williams, Nerissa T."'

1. The Effect of Atm Loss on Radiosensitivity of a Primary Mouse Model of Pten -Deleted Brainstem Glioma.

Author

Stewart, Connor E., Guerra-García, María E., Luo, Lixia, Williams, Nerissa T., Ma, Yan, Regal, Joshua A., Ghosh, Debosir, Sansone, Patrick, Oldham, Mark, Deland, Katherine, Becher, Oren J., Kirsch, David G., and Reitman, Zachary J.

Subjects
BIOLOGICAL models, PROTEIN kinases, GENETIC mutation, ANIMAL experimentation, PHOSPHOTRANSFERASES, GLIOMAS, TUMORS in children, RADIATION-sensitizing agents, GENETIC techniques, DNA damage, BRAIN stem, MICE, PHYSIOLOGICAL effects of radiation
Published
2022
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2. Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models.

Author

Deland, Katherine, Starr, Bryce F., Mercer, Joshua S., Byemerwa, Jovita, Crabtree, Donna M., Williams, Nerissa T., Lixia Luo, Yan Ma, Chen, Mark, Becher, Oren J., Kirsch, David G., Luo, Lixia, and Ma, Yan

Subjects
*GLIOMAS, *ATAXIA telangiectasia, *AUTOMATED teller machines, *BRAIN stem, *GENOTYPES, *CEREBELLUM degeneration, *CEREBELLAR tumors, *PROTEIN metabolism, *PROTEINS, *PROTEIN kinases, *RESEARCH, *GENETIC mutation, *CANCER cells, *POULTRY, *ANIMAL experimentation, *RESEARCH methodology, *RADIATION, *MEDICAL cooperation, *EVALUATION research, *COMPARATIVE studies, *OXIDOREDUCTASES, *CELL lines, *MICE
Abstract

Diffuse intrinsic pontine glioma (DIPG) kills more children than any other type of brain tumor. Despite clinical trials testing many chemotherapeutic agents, palliative radiotherapy remains the standard treatment. Here, we utilized Cre/loxP technology to show that deleting Ataxia telangiectasia mutated (Atm) in primary mouse models of DIPG can enhance tumor radiosensitivity. Genetic deletion of Atm improved survival of mice with p53-deficient but not p53 wild-type gliomas after radiotherapy. Similar to patients with DIPG, mice with p53 wild-type tumors had improved survival after radiotherapy independent of Atm deletion. Primary p53 wild-type tumor cell lines induced proapoptotic genes after radiation and repressed the NRF2 target, NAD(P)H quinone dehydrogenase 1 (Nqo1). Tumors lacking p53 and Ink4a/Arf expressed the highest level of Nqo1 and were most resistant to radiation, but deletion of Atm enhanced the radiation response. These results suggest that tumor genotype may determine whether inhibition of ATM during radiotherapy will be an effective clinical approach to treat DIPGs. [ABSTRACT FROM AUTHOR]

Published
2021
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