1. Hyperadiponectinemia enhances bone formation in mice.
- Author
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Mitsui, Yasuhiro, Gotoh, Masafumi, Fukushima, Nobuhiro, shirachi, Isao, Otabe, Shuichi, Yuan, Xiaohong, Hashinaga, Toshihiko, Wada, Nobuhiko, Mitsui, Akiko, Yoshida, Tatsuhiro, Yoshida, Shiro, Yamada, Kentaro, and Nagata, Kensei
- Subjects
ADIPONECTIN ,POLYPEPTIDES ,FAT cells ,BLOOD plasma ,ANIMAL models in research - Abstract
Background: There is growing evidence that adiponectin, a physiologically active polypeptide secreted by adipocytes, controls not only adipose tissue but also bone metabolism. However, a role for adiponectin in bone development remains controversial. Methods: We therefore investigated the endocrine effects of adiponectin on bone metabolism using 12-week-old male transgenic (Ad-Tg) mice with significant hyperadiponectinemia overexpressing human full-length adiponectin in the liver. Results: In Ad-Tg mice, the serum level of osteocalcin was significantly increased, but the levels of RANKL, osteoprotegerin, and TRAP5b were not. Bone mass was significantly greater in Ad-Tg mice with increased bone formation. In contrast, bone resorption parameters including the number of osteoclasts and eroded surface area did not differ between Ad-Tg and their littermates. Conclusions: These findings demonstrate that hyperadiponectinemia enhances bone formation in mice. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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