1. Screening of cell‐virus, cell‐cell, gene‐gene crosstalk among animal kingdom at single cell resolution
- Author
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Dongsheng Chen, Zhihua Ou, Jiacheng Zhu, Haoyu Wang, Peiwen Ding, Lihua Luo, Xiangning Ding, Chengcheng Sun, Tianming Lan, Sunil Kumar Sahu, Weiying Wu, Yuting Yuan, Wendi Wu, Jiaying Qiu, Yixin Zhu, Qizhen Yue, Yi Jia, Yanan Wei, Qiuyu Qin, Runchu Li, Wandong Zhao, Zhiyuan Lv, Mingyi Pu, Boqiong Lv, Shangchen Yang, Ashley Chang, Xiaofeng Wei, Fengzhen Chen, Tao Yang, Zhenyong Wei, Fan Yang, Peijing Zhang, Guoji Guo, Yuejiao Li, Yan Hua, and Huan Liu
- Subjects
SARS-CoV-2 ,Spike Glycoprotein, Coronavirus ,Animals ,COVID-19 ,Humans ,Receptors, Virus ,Molecular Medicine ,Medicine (miscellaneous) ,Host Specificity - Abstract
The exact animal origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains obscure and understanding its host range is vital for preventing interspecies transmission.Herein, we applied single-cell sequencing to multiple tissues of 20 species (30 data sets) and integrated them with public resources (45 data sets covering 26 species) to expand the virus receptor distribution investigation. While the binding affinity between virus and receptor is essential for viral infectivity, understanding the receptor distribution could predict the permissive organs and tissues when infection occurs.Based on the transcriptomic data, the expression profiles of receptor or associated entry factors for viruses capable of causing respiratory, blood, and brain diseases were described in detail. Conserved cellular connectomes and regulomes were also identified, revealing fundamental cell-cell and gene-gene cross-talks from reptiles to humans.Overall, our study provides a resource of the single-cell atlas of the animal kingdom which could help to identify the potential host range and tissue tropism of viruses and reveal the host-virus co-evolution.
- Published
- 2022
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