1. A Human Ex Vivo Skin Model to Study Candida auris Biofilms
- Author
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Dora E, Corzo-León, Catherine, Mark, Donna M, MacCallum, and Carol A, Munro
- Subjects
Antifungal Agents ,Biofilms ,Candida albicans ,Candidiasis ,Animals ,Humans ,Candida auris ,Candida - Abstract
Candida auris can persist for long periods on hospital surfaces and on the skin. C. auris has the ability to form drug-resistant biofilms, which can substantially impact on patient outcome. In comparison to Candida albicans, C. auris has a lower capacity to form biofilms in in vitro models and a higher capacity when tested on animal skin models. Intraspecies variation is shown to exist, with some clinical isolates having greater biofilm capabilities than others. There is a need for models that closely mimic the real niches where infection occurs on human patients. This protocol describes, in detail, a human skin model to study C. auris biofilm formation using catheterized and non-catheterized skin.
- Published
- 2022