1. Podocyte NADPH Oxidase 5 Promotes Renal Inflammation Regulated by the Toll-Like Receptor Pathway
- Author
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Eldjonai Kamto, Melica Novakovic, Naomi C. Boisvert, Khaled S. Abd-Elrahman, Jean-Francois Thibodeau, Stephen S. G. Ferguson, Chet E. Holterman, and Christopher R.J. Kennedy
- Subjects
Lipopolysaccharides ,0301 basic medicine ,medicine.medical_specialty ,Physiology ,Biopsy ,Toll-Like Receptor Pathway ,Kidney Glomerulus ,Clinical Biochemistry ,Gene Expression ,Mice, Transgenic ,medicine.disease_cause ,Biochemistry ,Proinflammatory cytokine ,Podocyte ,Mice ,03 medical and health sciences ,Internal medicine ,medicine ,Animals ,Phosphorylation ,Endothelial dysfunction ,Molecular Biology ,General Environmental Science ,Toll-like receptor ,Nephritis ,NADPH oxidase ,030102 biochemistry & molecular biology ,biology ,Podocytes ,Chemistry ,Macrophages ,Toll-Like Receptors ,Cell Biology ,medicine.disease ,Disease Models, Animal ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,NADPH Oxidase 5 ,biology.protein ,Cytokines ,General Earth and Planetary Sciences ,Inflammation Mediators ,Biomarkers ,Oxidative stress ,Signal Transduction ,Kidney disease - Abstract
Oxidative stress associated with a proinflammatory state occurs in endothelial dysfunction, hypertension, chronic kidney disease, and diabetes. The NADPH oxidase (Nox) family of reactive oxygen species (ROS) generating enzymes is implicated in these processes, yet little information regarding the role of Nox5 is available. Our aim was to investigate the role of Nox5 in promoting renal inflammation and identify mechanisms regulating its activity.Mice with podocyte-specific Nox5 (Nox5 more...
- Published
- 2019
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