Search

Your search keyword '"D. García de Jalón"' showing total 32 results
Start Over Author "D. García de Jalón" Topic animals
32 results on '"D. García de Jalón"'

8. [Concentration of biogenic amines in the central and peripheral nervous systems of rats with portacaval shunts, and their changes following administration of pargyline and levodopa]

Author

A, Alsasua, J, Arias, M L, López-Sánchez, E, Estébanez, J I, Arias, P D, García de Jalón, and H, Durán Sacristán

Subjects
Brain Chemistry, Levodopa, Male, Biogenic Amines, Pargyline, Hepatic Encephalopathy, Animals, Portasystemic Shunt, Surgical, Rats, Inbred Strains, Peripheral Nerves, Rats
Published
1982

14. [The receptor complex: current problems]

Author

P D, García de Jalón and J R, Ramón Jiménez

Subjects
Chlorides, Receptors, Drug, Cell Membrane, Animals, Lipid Metabolism, Ion Channels
Published
1984

21. [Kinetics of mexiletine distribution in the rat]

Author

S, Barrigón, J, Tamargo, and P D, García de Jalón

Subjects
Male, Kinetics, Propylamines, Injections, Intravenous, Administration, Oral, Animals, Mexiletine, Tissue Distribution, Rats
Published
1983

22. [Experimental portosystemic encephalopathy: values of noradrenaline, dopamine, and homovanillic acid in the CNS of rats at 15, 30 and 60 days after terminolateral porto-caval anastomosis]

Author

J, Arias, A, Alsasua, E, Estebánez, M L, López, J I, Arias, M, Durán, P D, García de Jalón, and H, Durán Sacristán

Subjects
Brain Chemistry, Male, Brain Diseases, Norepinephrine, Postoperative Complications, Time Factors, Portacaval Shunt, Surgical, Dopamine, Animals, Homovanillic Acid, Phenylacetates, Rats
Published
1982

23. Metabolism and kinetics of renal elimination of N-picolyl-3,5-dimethylbenzamides

Author

P D, García de Jalón, E, González Fernández, A, Idoipe, M R, Martínez Larrañaga, and M F, Braña

Subjects
Male, Chemistry, Kinetics, Chemical Phenomena, Benzamides, Animals, Central Nervous System Depressants, Rats
Abstract

The metabolism and kinetics of renal elimination of N-(2-picolyl)-, N-(3-picolyl)- and N-(4-picolyl)-3,5-dimethylbenzamides were studied. These products have a depressive activity on the central nervous system, as well as an anti-inflammatory and spasmolytic activity. The elimination of the products N-(3-picolyl)- and N-(4-picolyl)-3,5-dimethylbenzamides includes a process of metabolic oxidization of the atom of pyridinic nitrogen with formation of the corresponding N-oxides as main products of its bio-transformation. The process of N-oxidization was not observed with the product N-(2-picolyl)-3,5-dimethyl-benzamide. The results showed that the renal elimination rate of the products studied is greater as the pyridinic nitrogen moves away from the amide group. In the biotransformation process of these products, there is an opposite effect, i.e., the formation of corresponding N-oxides is lower as the pyridinic nitrogen approaches the amide group.

Published
1979

Catalog

Books, media, physical & digital resources
See catalog results