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1. 17-esters and 17,21-diesters of 9-alpha, 11-beta-dichlorocorticoids. Synthesis and anti-inflammatory activity

Author

Hershel L. Herzog, I.I.A. Tabachnick, Lois Weber, Elliott J. Collins, Finckenor Lawrence E, Oliveto Eugene P, Robinson Cecil H, Hubert Pluchet, and Elliot L. Shapiro

Subjects
Pharmacology, Chemistry, medicine.drug_class, Dichlorisone, Organic Chemistry, Clinical Biochemistry, Anti-Inflammatory Agents, Chemistry, Organic, medicine.disease, Biochemistry, Anti-inflammatory, Organic Chemistry Phenomena, Rats, Endocrinology, Granuloma, Immunology, medicine, Animals, Steroids, Pouch, Molecular Biology, Skin
Abstract

The syntheses of some 17,21-diesters of dichlorisone (9α, 11β-dichloro-17α, 21-dihydroxy-1,4-pregnadiene-3, 20-dione), 16α-methyldichlorisone and 16β-methyldichlorisone and some 17-monoesters of 16α-methyldichlorisone are reported. Anti-inflammatory activity, as measured by a granuloma pouch technique, reached a maximum for the 17-butyrate and 17-valerate of 16α-methyldichlorisone and for the 17, 21-dipropionate and 17, 21-dibutyrate of 16α-methyldichlorisone.

Published
1967

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