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Your search keyword '"Guichao Xu"' showing total 2 results
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2 results on '"Guichao Xu"'

1. Design, synthesis and evaluation of a novel class of glucosamine mimetic peptides containing 1,3-dioxane

Author

Li Zeng, Jianwei Zhang, Pengchao Gao, Meng Zhang, Hong Li, and Guichao Xu

Subjects
Male, Pharmacology, chemistry.chemical_classification, Glucosamine, Mice, Inbred ICR, Molecular Structure, Amino sugar, Stereochemistry, Organic Chemistry, Anti-Inflammatory Agents, General Medicine, Dioxanes, Mice, chemistry.chemical_compound, chemistry, Design synthesis, Drug Design, Drug Discovery, Animals, Edema, Organic chemistry, Peptidomimetics
Abstract

A number of novel 2-(N-(2-(5,5-dimethyl-1,3-dioxane-2-yl)ethyl)aminoacyl)amino-2-deoxy- d-glucopyranoside were synthesized from a readily available starting material, glucosamine, 2,2-dimethyl-1,3-propanediol and 1,1,3,3-tetramethoxypropane, and evaluated for their anti-inflammatory activity. Our results showed that all of the compounds tested exhibited a significant inhibition of xylene-induced inflammation in mice.

Published
2015
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2. Synthesis and biological evaluation of a novel class of coumarin derivatives

Author

Hong Li, Pengchao Gao, Qing Sun, Wang Xiaomin, Jianwei Zhang, Wei Liao, Kai Cheng, Li Zeng, and Guichao Xu

Subjects
Cell Survival, Clinical Biochemistry, Intercalation (chemistry), Transplantation, Heterologous, Pharmaceutical Science, Peptide, Antineoplastic Agents, Biochemistry, chemistry.chemical_compound, Mice, Coumarins, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Animals, Humans, heterocyclic compounds, Doxorubicin, Cytotoxicity, Molecular Biology, chemistry.chemical_classification, Chemistry, Circular Dichroism, Organic Chemistry, DNA, Coumarin, In vitro, Amino acid, Molecular Medicine, Cattle, medicine.drug
Abstract

In this study, several novel coumarin derivatives, 7-hydroxy-2-oxo-2H-chromene-3-carboxyl-Trp-Trp-AA-OBzl compounds, were designed and synthesized as potential anticancer agents. Their in vitro cytotoxic activities were evaluated using methylthiazoltetrazolium (MTT) assay. The anti-tumor activity of the newly coumarin derivatives was determined in a S180 bearing mouse model and some of the compounds demonstrated tumor growth inhibition similar to the positive control, doxorubicin. Compared to doxorubicin, most of the compounds exhibited enhanced immunologic function suggesting a relatively minor toxic effect. The intercalation of the coumarin derivatives synthesized with calf thymus (CT) DNA was also studied.

Published
2014

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