1. Microbiota manipulation to increase macrophage IL-10 improves colitis and limits colitis-associated colorectal cancer
- Author
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Daniel F. Zegarra Ruiz, Dasom V. Kim, Kendra Norwood, Fatima B. Saldana-Morales, Myunghoo Kim, Charles Ng, Ryann Callaghan, Maisha Uddin, Lin-Chun Chang, Randy S. Longman, and Gretchen E. Diehl
- Subjects
Inflammation ,Microbiology (medical) ,Macrophages ,Microbiota ,Gastroenterology ,Colitis ,Inflammatory Bowel Diseases ,Microbiology ,Gastrointestinal Microbiome ,Interleukin-10 ,Disease Models, Animal ,Infectious Diseases ,Escherichia coli ,Animals ,Humans ,Colitis-Associated Neoplasms - Abstract
Inflammatory bowel disease (IBD) is a chronic life-long inflammatory disease affecting almost 2 million Americans. Although new biologic therapies have been developed, the standard medical treatment fails to selectively control the dysregulated immune pathways involved in chronic colonic inflammation. Further, IBD patients with uncontrolled colonic inflammation are at a higher risk for developing colorectal cancer (CRC). Intestinal microbes can impact many immune functions, and here we asked if they could be used to improve intestinal inflammation. By utilizing an intestinal adherent
- Published
- 2022
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