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Your search keyword '"Podesta, L."' showing total 3 results
Start Over Author "Podesta, L." Topic animals
3 results on '"Podesta, L."'

1. Amelioration of Normothermic Canine Liver Ischemia With Prostacyclin

Author

Todo, S., Yokoi, H., Podesta, L., ChapChap, P., Pan, C., Okuda, K., Kamiyama, Y., Demetris, J., Makowka, L., Iwatsuki, S., and Starzl, T.E.

Subjects
Dogs, Liver, Ischemia, Animals, Epoprostenol, Article
Abstract

A model of hepatic ischemia was developed in dogs using a pump-driven splanchnic-to-jugular vein bypass during crossclamping of the portal triad. An LD50 was established with three hours of ischemia. PGI2 given for one hour before the ischemic insult ameliorated the ischemic injury and increased survival.

Published
1988

2. Orthotopic Liver Transplantation in Dogs Receiving FK-506

Author

Todo, S., Podesta, L., ChapChap, P., Kahn, D., Pan, C-E., Ueda, Y., Okuda, K., Imventarza, O., Casavilla, A., Demetris, A.J., Makowka, L., and Starzl, T.E.

Subjects
Graft Rejection, Dogs, Liver Function Tests, Pyridines, Body Weight, Drug Evaluation, Preclinical, Animals, Article, Immunosuppressive Agents, Tacrolimus, Liver Transplantation
Abstract

Ten dogs that survived the perioperative events of liver transplantation were treated with 1 mg/kg/d oral FK. Eight of the recipients lived for at least 1 month postoperatively, and seven are still alive with normal hepatic function after 35 to 65 days. The consistency and good quality of results with this difficult transplant preparation using FK, in spite of its rumored great toxicity in dogs, have highlighted the importance of further developing the drug.

Published
1987

3. Effect of FK506 in Experimental Organ Transplantation

Author

Todo, S., Murase, N., Ueda, Y., Podesta, L., ChapChap, P., Kahn, D., Okuda, K., Imventarza, O., Casavilla, A., Demetris, J., Makowka, L., and Starzl, T.E.

Subjects
Graft Rejection, Pyridines, Transplantation, Heterologous, Drug Evaluation, Preclinical, Cyclosporins, Kidney Transplantation, Article, Tacrolimus, Liver Transplantation, Rats, Rats, Inbred ACI, Dogs, Rats, Inbred Lew, Rats, Inbred BN, Animals, Heart Transplantation, Prednisone, Transplantation, Homologous, Drug Therapy, Combination, Kidney Diseases, Immunosuppressive Agents
Abstract

FK506 is the most potent immunosuppressive agent known. Its toxicity is substantial in dogs, minor in rats, and unknown in subhuman primates. In small doses that are nontoxic even in dogs, it can be used in synergistic combination with cyclosporine, steroids, and presumably in other drugs.

Published
1988

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