1. Synthesis and study of some new N-substituted imide derivatives as potential anticancer agents
- Author
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Rolf W. Hartmann, Anja Palusczak, Dharam Paul Jindal, Ranju Bansal, Nalin Karkra, Vikas Bedi, Sheetal Guleria, and Birinder Jit
- Subjects
Phthalic anhydride ,Molecular Structure ,Hydrobromide ,Aromatase Inhibitors ,Cell Survival ,Aryl ,Pharmaceutical Science ,Antineoplastic Agents ,General Medicine ,Imides ,Combinatorial chemistry ,chemistry.chemical_compound ,Structure-Activity Relationship ,chemistry ,Cell Line, Tumor ,Drug Discovery ,medicine ,Organic chemistry ,Animals ,Humans ,Hydrazine (antidepressant) ,Naphthalic anhydride ,Imide ,Aminoglutethimide ,medicine.drug - Abstract
A new series of N-substituted imide derivatives have been synthesized by treating phthalic anhydride, naphthalic anhydride and their substituted derivatives with 2-hydrazino-1-imidazoline hydrobromide, various para-substituted aryl amines, aminoglutethimide and 2,4-dinitrophenyl hydrazine. Compounds 9, 10, 12, 18, 19, 23, 24 and 34-36 have been selected and screened for antineoplastic activity by National Cancer Institute, Bethesda, USA. Some newer aminoglutethimide derivatives 37-39 have also been prepared in order to study the effect of N-substitution on its pharmacological profile for the treatment of carcinoma. These compounds (37-39) have exhibited weak inhibition of human placental aromatase as compared to aminoglutethimide.
- Published
- 2004