1. Psychological stress effects on myelin degradation in the cuprizone-induced model of demyelination
- Author
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Ali Akbar Saboury, Saeed Karima, Amirbahador Zeynali, Gholam Hossein Riazi, Monireh-Sadat Mousavi, Shahin Ahmadian, Pouya Sharif Dashti, Sogol Meknatkhah, Meknatkhah, S, Sharif Dashti, P, Mousavi, M, Zeynali, A, Ahmadian, S, Karima, S, Saboury, A, and Riazi, G
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,psychological stre ,Disease ,Luxol fast blue stain ,Corpus Callosum ,Pathology and Forensic Medicine ,Cuprizone ,03 medical and health sciences ,Myelin ,0302 clinical medicine ,Demyelinating disease ,medicine ,Animals ,Rats, Wistar ,Myelin Sheath ,biology ,business.industry ,Multiple sclerosis ,General Medicine ,medicine.disease ,physical stre ,Myelin basic protein ,Staining ,Disease Models, Animal ,030104 developmental biology ,medicine.anatomical_structure ,cuprizone model ,multiple sclerosi ,biology.protein ,Immunohistochemistry ,Female ,demyelination ,Neurology (clinical) ,business ,Stress, Psychological ,030217 neurology & neurosurgery ,Demyelinating Diseases - Abstract
Multiple sclerosis (MS) is known as the most common demyelinating disease worldwide in which previous studies have shown that stress is a risk factor for the disease's onset and progression. Nevertheless, further studies are needed to investigate the consequences of stress in MS pathology. In this study, after 5 days of exposure to psychological and physical stress as a repetitive distress modality, rats were treated with cuprizone. The demyelination degree was compared in animal groups using Luxol fast blue staining, immunohistochemical staining for myelin basic protein and transmission electron microscopy. Outcomes revealed that animals exposed to stress prior to cuprizone ingestion, elicit more intense demyelination. Continuous psychological distress has more severe effects on myelin sheath destruction in the preclinical stage.
- Published
- 2019