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Bupropion is used to help people stop smoking. This drug can cause visual alterations but, up to now, its use was not associated with anisocoria.A 40 year-old woman with a personal history of migraines, presented with monocular mydriasis during treatment with bupropion. Both pupils dilated equally after a 5% cocaine test, and constricted equally after a 0.025% Pilocarpine test. The anisocoria disappeared after the treatment with bupropion was withdrawn.Bupropion inhibits neural uptake of norepinephrine and dopamine. Patients with migraine could have a minor unilateral sympathetic pupillary deficit. This deficit could cause hypersensitivity in the oculosympathetic pathway that could be stimulated with bupropion treatment. This feature could explain the mydriasis in our patient. Another explanation could be that bupropion could unmask a physiological anisocoria.

Introducción: El bupropión se usa como deshabituante del hábito tabáquico. Puede provocar alteraciones visuales, pero hasta el momento no se había comunicado la aparición de anisocoria. Caso clínico: Mujer de 40 años con migrañas, en tratamiento con bupropión presentó midriasis monocular. Instilando cocaína al 5%, ambas pupilas dilataron de la misma manera. Con pilocarpina 0,025% ambas pupilas contrajeron de forma similar. La anisocoria cesó al suspender el tratamiento. Discusión: El bupropión es inhibidor selectivo de la recaptación de noradrenalina y dopamina. La vía pupilar simpática podría tener una cierta hipersensibilidad en pacientes migrañosos por denervación que podría estimularse con el tratamiento con estos fármacos, lo que explicaría la anisocoria. Por otra parte el estímulo midriático del bupropion podría haber desenmascarado una anisocoria fisiológica. Introduction: Bupropion is used to help people stop smoking. This drug can cause visual alterations but, up to now, its use was not associated with anisocoria. Case report: A 40 year-old woman with a personal history of migraines, presented with monocular mydriasis during treatment with bupropion. Both pupils dilated equally after a 5% cocaine test, and constricted equally after a 0.025% Pilocarpine test. The anisocoria disappeared after the treatment with bupropion was withdrawn. Discussion: Bupropion inhibits neural uptake of norepinephrine and dopamine. Patients with migraine could have a minor unilateral sympathetic pupillary deficit. This deficit could cause hypersensitivity in the oculosympathetic pathway that could be stimulated with bupropion treatment. This feature could explain the mydriasis in our patient. Another explanation could be that bupropion could unmask a physiological anisocoria.