1. Cobalt/Salox‐Catalyzed Enantioselective C−H Functionalization of Arylphosphinamides.
- Author
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Yao, Qi‐Jun, Chen, Jia‐Hao, Song, Hong, Huang, Fan‐Rui, and Shi, Bing‐Feng
- Abstract
Previous methods on CoIII‐catalyzed asymmetric C−H activation rely on the use of tailor‐made cyclopentadienyl‐ligated CoIII complexes, which require lengthy steps for the preparation. Herein, we report an unprecedented enantioselective C−H functionalization enabled by a simple cobalt/salicyloxazoline (Salox) catalysis. The chiral Salox ligands can be easily prepared in one step from salicylonitrile and chiral amino alcohols. A broad range of P‐stereogenic compounds were synthesized in high yields with excellent enantioselectivities (45 examples, up to 99 % yield and >99 % ee). The isolation and characterization of several intermediates provided insights into the generation of active catalytic cobalt species, the action of Salox, and the mode of stereocontrol. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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