1. Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region.
- Author
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Ferreira WA, Ferreira CM, Naveca FG, Almeida NC, Vasconcelos Wde S, Gomes Jde S, Silva Mde F, and Alecrim Md
- Subjects
- Adult, Brazil, Genotype, Gonorrhea diagnosis, Gonorrhea drug therapy, Humans, Male, Microbial Sensitivity Tests, Neisseria gonorrhoeae drug effects, Neisseria gonorrhoeae isolation & purification, Phenotype, Anti-Bacterial Agents pharmacology, Ciprofloxacin pharmacology, Drug Resistance, Bacterial genetics, Gonorrhea microbiology, Neisseria gonorrhoeae genetics, Ofloxacin pharmacology
- Abstract
We report two ciprofloxacin and ofloxacin-resistant Neisseria gonorrhoeae strains that were isolated from the urethral discharge of male patients at the sexually transmitted diseases outpatient clinic of the Alfredo da Matta Foundation (Manaus, state of Amazonas, Brazil). The gonococci displayed minimal inhibitory concentrations (> 32.00 µg/mL) and three mutations in the quinolone resistance-determining region (S91F and D95G in GyrA and S87R in ParC). Both isolates were genotyped using N. gonorrhoeae multi-antigen sequence typing and the analysis showed that the ST225 which represented an emerging widespread multi-resistant clone that has also been associated with reduced susceptibility to ceftriaxone. We recommend continued surveillance of this pathogen to assess the efficacy of anti-gonococcal antibiotics in Brazil.
- Published
- 2011
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