1. Bronchopulmonary infection-colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study.
- Author
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de Dios Caballero J, Del Campo R, Royuela A, Solé A, Máiz L, Olveira C, Quintana-Gallego E, de Gracia J, Cobo M, de la Pedrosa EG, Oliver A, and Cantón R
- Subjects
- Adolescent, Adult, Child, Coinfection drug therapy, Coinfection epidemiology, Coinfection physiopathology, Female, Humans, Male, Prevalence, Prospective Studies, Respiratory Function Tests methods, Spain epidemiology, Anti-Bacterial Agents therapeutic use, Cystic Fibrosis epidemiology, Cystic Fibrosis microbiology, Cystic Fibrosis physiopathology, Lung microbiology, Lung physiopathology, Methicillin-Resistant Staphylococcus aureus isolation & purification, Pseudomonas Infections drug therapy, Pseudomonas Infections epidemiology, Pseudomonas Infections physiopathology, Pseudomonas aeruginosa isolation & purification, Staphylococcal Infections drug therapy, Staphylococcal Infections epidemiology, Staphylococcal Infections physiopathology
- Abstract
Background: Clinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented., Methods: 24 CF-Units for adult (n=12) and pediatric (n=12) patients from 17 hospitals provided sputa and clinical data from 15 consecutive patients. Cultures and susceptibility testing were performed. Colonization impact on pulmonary function was assessed., Results: 341 patients [mean (SD) age 21 (11) years, 180≥18years, mean (SD) FEV1=68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (p<0.001 and p=0.003, respectively)., Conclusions: The representative subset of the Spanish CF-population which has been clinically, demographically and microbiologically characterized will serve as a reference for future CF studies in Spain., (Copyright © 2015 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.)
- Published
- 2016
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