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1. Effect of composition on the physicochemical properties and active substance release from gelatin-alginate sponge.

Author

Haznar D and Pluta J

Subjects
Alginates pharmacokinetics, Drug Compounding, Freeze Drying, Gelatin, Gelatin Sponge, Absorbable pharmacokinetics, Glycerol chemistry, Peanut Oil, Plant Oils chemistry, Polymers chemistry, Alginates chemical synthesis, Alginates chemistry, Anti-Bacterial Agents pharmacokinetics, Cephradine pharmacokinetics, Drug Carriers, Gelatin Sponge, Absorbable chemical synthesis, Glucuronic Acid chemistry, Hexuronic Acids chemistry
Abstract

The aim the study was physicochemically characterize and develop ability of the active substance (cefradine) from the implantable porous carriers. The drug delivery systems consisting of the gelatine and alginic acid sodium salt and glycerol (GL) or peanut oil (AO). Gelatin-alginate sponge was prepared by foamed components and next freeze-dried this foam. The composition of the sponges affected on the sorption ability and on the stability to proteolytic enzymes. Owing to porous structure obtained specific profile of active substance release.

Published
2003

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