1. Coinfections of Two Strains of NDM-1- and OXA-232-Coproducing Klebsiella pneumoniae in a Kidney Transplant Patient.
- Author
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Contreras DA, Fitzwater SP, Nanayakkara DD, Schaenman J, Aldrovandi GM, Garner OB, and Yang S
- Subjects
- Aged, Coinfection, Female, Humans, Kidney Transplantation adverse effects, Klebsiella Infections mortality, Klebsiella pneumoniae genetics, Klebsiella pneumoniae isolation & purification, Methyltransferases genetics, Microbial Sensitivity Tests, Plasmids genetics, Anti-Bacterial Agents therapeutic use, Klebsiella Infections drug therapy, Klebsiella pneumoniae drug effects, beta-Lactamases genetics
- Abstract
We report here a fatal case of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections in a renal transplant patient without a travel history in the prior year, from whom 2 genetically different CRKP (sequence type 14 [ST14] and ST2497) strains carrying the same plasmids and antimicrobial resistance genes, including bla
NDM-1 , blaOXA-232 , blaCTX-M-15 , armA , and tet (D), were isolated from blood and the abdominal cavity. The isolates were susceptible to colistin, tigecycline, eravacycline, and cefiderocol, which was used to treat the CRKP in combination with ceftazidime-avibactam and polymyxin B and resulted in bacterial clearance. Despite the aggressive treatment, the patient died of ischemic colitis and multiorgan failure., (Copyright © 2020 American Society for Microbiology.)- Published
- 2020
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