1. Increased Antibacterial and Antibiofilm Properties of Silver Nanoparticles Using Silver Fluoride as Precursor.
- Author
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Bertoglio F, De Vita L, D'Agostino A, Diaz Fernandez Y, Falqui A, Casu A, Merli D, Milanese C, Rossi S, Taglietti A, Visai L, and Pallavicini P
- Subjects
- Anti-Bacterial Agents pharmacology, Escherichia coli drug effects, Escherichia coli physiology, Plankton drug effects, Plankton microbiology, Staphylococcus epidermidis drug effects, Staphylococcus epidermidis physiology, Anti-Bacterial Agents chemistry, Biofilms drug effects, Fluorides chemistry, Metal Nanoparticles chemistry, Silver chemistry, Silver Compounds chemistry
- Abstract
Silver nanoparticles were produced with AgF as the starting Ag(I) salt, with pectin as the reductant and protecting agent. While the obtained nanoparticles (pAgNP-F) have the same dimensional and physicochemical properties as those already described by us and obtained from AgNO
3 and pectin (pAgNP-N), the silver nanoparticles from AgF display an increased antibacterial activity against E. coli PHL628 and Staphylococcus epidermidis RP62A ( S. epidermidis RP62A), both as planktonic strains and as their biofilms with respect to pAgNP-N. In particular, a comparison of the antimicrobial and antibiofilm action of pAgNP-F has been carried out with pAgNP-N, pAgNP-N and added NaF, pure AgNO3 , pure AgF, AgNO3 and added NaF and pure NaNO3 and NaF salts. By also measuring the concentration of the Ag+ cation released by pAgNP-F and pAgNP-N, we were able to unravel the separate contributions of each potential antibacterial agent, observing an evident synergy between p-AgNP and the F- anion: the F- anion increases the antibacterial power of the p-AgNP solutions even when F- is just 10 µM, a concentration at which F- alone (i.e., as its Na+ salt) is completely ineffective.- Published
- 2020
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