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Your search keyword '"Pranteda, Guglielmo"' showing total 2 results
Start Over Author "Pranteda, Guglielmo" Topic anti-bacterial agents
2 results on '"Pranteda, Guglielmo"'

1. Pitted keratolysis, erythromycin, and hyperhidrosis.

Author

Pranteda G, Carlesimo M, Pranteda G, Abruzzese C, Grimaldi M, De Micco S, Muscianese M, and Bottoni U

Subjects
Administration, Cutaneous, Adolescent, Adult, Anti-Bacterial Agents administration & dosage, Child, Drug Administration Schedule, Erythromycin administration & dosage, Female, Gels, Humans, Hyperhidrosis diagnosis, Hyperhidrosis physiopathology, Italy, Male, Middle Aged, Skin Diseases, Bacterial complications, Skin Diseases, Bacterial diagnosis, Skin Diseases, Bacterial microbiology, Sweating, Time Factors, Treatment Outcome, Young Adult, Anti-Bacterial Agents therapeutic use, Erythromycin therapeutic use, Hyperhidrosis microbiology, Skin Diseases, Bacterial drug therapy
Abstract

Pitted keratolysis (PK) is a plantar skin disorder mainly caused by coryneform bacteria. A common treatment consists of the topical use of erythromycin. Hyperhidrosis is considered a predisposing factor for bacterial proliferation and, consequently, for the onset of PK. The aim of this study was to evaluate the relationship between PK erythromycin and hyperhidrosis. All patients with PK seen in Sant'Andrea Hospital, between January 2009 and December 2011, were collected. PK was clinically and microscopically diagnosed. All patients underwent only topical treatment with erythromycin 3% gel twice daily. At the beginning of the study and after 5 and 10 days of treatment, a clinical evaluation and a gravimetric measurement of plantar sweating were assessed. A total of 97 patients were diagnosed as PK and were included in the study. Gravimetric measurements showed that in 94 of 97 examined patients (96.90%) at the time of the diagnosis, there was a bilateral excessive sweating occurring specifically in the areas affected by PK. After 10 days of antibiotic therapy, hyperhidrosis regressed together with the clinical manifestations. According to these data, we hypothesize that hyperhidrosis is due to an eccrine sweat gland hyperfunction, probably secondary to bacterial infection., (© 2013 Wiley Periodicals, Inc.)

Published
2014
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2. Multiple skin ulcers due to Serratia marcescens in an immunocompetent patient

Author

Marta CARLESIMO, Pennica, Alfredo, Muscianese, M., ugo bottoni, Abruzzese, Claudia, Giubettini, Maria, Pranteda, Guglielmo, and Pranteda, Giulia

Subjects
Immunocompetence, Pyoderma gangrenosum, Serratia marcescens, 2708, Male, Adolescent, Pyoderma Gangrenosum, Anti-Bacterial Agents, Serratia Infections, Diagnosis, Differential, Treatment Outcome, Ciprofloxacin, Skin Ulcer, Humans
Abstract

Serratia marcescens is a species of gram negative bacillus, classified as a member of the Enterobacteriaceae, mainly involved in opportunistic infections, particulary in the hospital environment. Cutaneous infections have rarely reported in literature and are predominantly observed in elderly or in immunocompromised patients. The clinical manifestations of skin infections include granulomatous lesions, necrotizing fasciitis, nodules, cellulitis, ulcers, dermal abscesses. Infections caused by S. marcescens may be difficult to treat because of resistance to a variety of antibiotics, including ampicillin and first and second generation cephalosporins. Aminoglycosides have good activity against S. marcescens, but resistant strains have also been described. We report a very intriguing case of S. marcescens infection, in an immunocompetent 18-year-old man, causing multiple rounded ulcers of varying sizes, along with few pustular lesions that both clinically and histopathologically mimic a pyoderma gangrenosum (PG). This is a non infectious neutrophilic skin disorder, characterized by painful and rapidly progressing skin ulceration. According to our experience, we would strongly recommend to perform cultures of multiple skin ulcers resembling PG, even in young healthy patients, to ensure correct diagnosis and treatment, since resistant to conventional antibiotics bacteria such as S. marcescens may be the cause of these lesions, like in the case here reported.

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